San antonio breast cancer symposium azure

As of October 18, , with a median follow-up of 5. First IDFS events were similar in both arms, such as locoregional recurrence 66 cases in the zoledronic acid arm and the control group and distant recurrence cases in the zoledronic acid arm and in controls. Coleman said; i. This was not a small group, with 1, women who were five years postmenopause. Coleman stressed this was a secondary outcome, so it could not be considered conclusive.

The dose was then tapered down to every three months for eight doses and then every six months for five doses to complete five years of treatment. Patients were similar in both arms of the study, including tumor stage, number of positive axillary nodes, chemotherapy type, estrogen-receptor status, menopausal status, and statin use.

There were 1, patients in the zoledronic acid treatment arm and 1, controls. The addition of zoledronic acid to standard treatment did not significantly impact the delivery of chemotherapy. As of October 18, , with a median follow-up of 5. Genetic testing during treatment can improve accuracy of response and outcome prediction compared to other prognostic tests, according to results from a study assessing on-treatment changes in gene expression in patients receiving chemotherapy.

Few women with metastatic breast cancer live five years or longer, and predictors of long-term survival are not well understood. Current guidelines recommend asymptomatic surveillance of breast cancer only for the detection of locoregional recurrences. Researchers from the Asan Medical Center in Seoul, Republic of Korea, conducted a retrospective year survival analysis of a large cohort of patients with recurrent breast cancer to identify the impact of early detection on survival outcomes and presented the findings at the San Antonio Breast Cancer Symposium on December 5, Access to quality breast cancer screening and treatment may contribute to racial disparities outcomes.

In , researchers at the urban safety net Cook County Health and Hospitals System in Chicago, IL, implemented changes in mammography practices, which included installing digital machines at one of four sites, centralizing reading of images at a single site with radiologists specialized in mammography, and increasing care coordination such as enhanced patient outreach efforts.

The efforts improved screening volume and cancer detection, according to the results presented at the San Antonio Breast Cancer Symposium on December 5, Surgical modality and receipt of chemotherapy or radiotherapy are not associated with sexual function, as measured by the Female Sexual Function Index FSFI. Patients receiving endocrine therapy with an aromatase inhibitor had significantly lower sexual function scores than those who received no endocrine therapy or those on tamoxifen, said a group of U.

The uptake of prophylactic surgeries among Latinas with germline BRCA mutations may be slightly lower than what has been reported in non-Hispanic whites but higher than in African Americans, a group of U. Exercise—preferably supervised—represents a viable intervention for prevention and treatment of fatigue among patients with breast cancer, a group of Australian, European, and U. The presence of type 2 diabetes mellitus at the time of breast cancer diagnosis has been suggested to adversely affect survival—independent of breast cancer stage, grade, and tumor phenotype—but few of those studies included people of Hispanic descent.

Researchers from Johns Hopkins Bloomberg School of Public Health in Baltimore and the University of Louisville in Kentucky examined the association between self-reported diabetes history, breast cancer-specific and all-cause mortality among Hispanic and non-Hispanic white women diagnosed with breast cancer. Ongoing and increasing evidence suggest that an equivalent rate of mutations may be found regardless of whether patients meet current testing criteria, according to a large group of community breast physicians.

Metabolic syndrome is associated with increased risk of cardiovascular disease, type 2 diabetes, and possibly cancer recurrence, and its occurrence is higher in breast cancer survivors than age-matched postmenopausal women.

Now, a study on exercise has found that aerobic and resistance exercise intervention reduced metabolic syndrome in sedentary, overweight, and obese Hispanic breast cancer survivors. Patients with breast cancer who are younger than 40 years are likely to have unfavorable subtypes, higher stage, and lower overall survival and disease-free survival DFS as compared to their older counterparts, according to researchers at the Roswell Park Cancer Institute in Buffalo, NY.

Vitamin D deficiency is associated with the inability to reach pathologic complete response pCR in patients with breast cancer undergoing neoadjuvant systemic chemotherapy NAC , and a trend for worse survival was seen in patients with triple negative tumors. Whole breast radiation therapy in isocentric lateral decubitus position is well tolerated with good cosmesis and low rates of fibrosis, said a group that had previously confirmed the efficacy and safety of the technique.

A group of German researchers attempting to identify predictors for a decision against an antihormonal treatment AHT were unable to show that patients benefited from chemotherapy. The first study on the mutational landscape of breast cancer diagnosed during pregnancy BCP using whole-genome sequencing found that BCP is associated with a higher number of putative driver mutations, including mutations in mucin genes. Researchers from Johns Hopkins University in Baltimore have found that adding the histone deacetylase inhibitor entinostat ENT to checkpoint inhibition decreases tumor burden and improves survival in human epidermal growth factor receptor 2 HER2 -positive breast cancer models.

The novel combination of estrogen receptor ER coregulator binding modulator ERX and palbociclib may delay, or even overcome, endocrine therapy resistance in women with ER-positive advanced breast cancer, according to a group of researchers from the University of Texas UT Healthcare System.

Despite interventions to bridge the gap in cancer disparities between African American and white women, racial disparities in breast cancer mortality exist. The National Cancer Institute reported that African American women have a higher mortality rate from breast cancer as compared to Caucasian women